Urmie Plein graduated from the Utrecht School of the Arts in 1993. After graduating, Urmie played in many different theatrical performances, as well as in films and television series. Between 2014 and 2016, she played Doloris in the successful TV series Amsterdam-E.V.A.
In 2016, she played in the theatre version of the popular Intouchables, which will reprise in 2020, as will the ITA play the Falling Man by Julien Gosselin.
Recently she could be seen in the series De Twaalf van Schouwendam, Baantjer: The Beginning and the second season of Meisje van Plezier.
In 2020 Urmie features in the series Red Light devised by Carice van Houten and Halina Reijn. Moreover, she can be seen in her solo performance Suriname Monologen about Anton de Kom.