During his second year at the Maastricht Academy of Dramatic Arts, Xander van Vledder was already noticed by the director of the Nationale Toneel. Less than a year after graduating, he joined the company’s permanent ensemble, which is now known as Het Nationale Theater. Later, he also performed with companies such as Het Toneel Speelt, De Theatercompagnie, and Het Zuidelijk Toneel.

Xander was part of the hit musical Soldaat van Oranje for an extended period and was nominated for a Musical Award for his lead role in Willem Ruis: De Show van Zijn Leven.

On television, Xander became widely known for his roles in series such as Feuten, Van Gogh: Een Huis voor Vincent, and De Maatschap, in which he portrayed one of the Moszkowicz brothers. He also appeared in television series such as Vliegende Hollanders, Papadag, Hoogvliegers, Dertigers, and Onopgelost.

As a director, Xander worked on productions such as De Drang and Dronken Mensen with his own theater company, Dronken Mensen.

Recently, Xander performed in productions such as De Avond is Ongemak, Het Pauperparadijs, and Zalf & Papaver.

In 2024, during the Holland Festival, Xander participated in the production The Second Woman and performed in Geweld & Vibrato as part of the Opera Festival.