Hylke van Sprundel graduated from the Theatre Academy in Maastricht in 1993, with a nomination for the Henriëtte Hustinx Award. After this, he performed in roles for several theatre companies.
He played a role in Midsummernightsdream, winner of the 2002 NRC Audience Award. In 2014-2016, he starred in the Dutch version of Warhorse.
He has played various roles on television, including the lead role in the drama series Zebra and the part of Prince Bernard in Juliana. In 2019, Hylke starred in the British series Van Der Valk.
The series De Vliegende Hollanders and Hoogvliegers will be aired in 2020.